ROL DE LA AUTOFAGIA EN LA ETIOPATOGÉNESIS DEL CÁNCER ORAL. REVISIÓN SISTEMÁTICA EXPLORATORIA

Francisca López; Arelys Moreno; Silvana Reyes; Marcelo Sánchez

doi:10.1590/SciELOPreprints.5094

##article.authors##

Francisca López University of Talca https://orcid.org/0000-0001-8156-1667
Arelys Moreno University of Talca
Silvana Reyes University of Talca https://orcid.org/0000-0003-1910-8938
Marcelo Sánchez University of Talca

DOI:

https://doi.org/10.1590/SciELOPreprints.5094

Keywords:

Autophagy, Neoplasms of the mouth, Carcinogenesis, Squamous Cell Carcinoma of the Head and Neck

Abstract

In this exploratory systematic review, we present the evidence recorded in the literature, that autophagy can generate both a procancer and anticancer action, acting through various mechanisms in which the autophagy process can be increased, decreased, or altered, through the activation of intracellular signaling pathways. Currently, there is sufficient evidence to support the association between autophagy and different types of cancer, however, there is no review that brings together the various mechanisms by which the autophagic process participates in its development and/or suppression. It was possible to show that there are various mechanisms by which autophagy participates in the development of oral carcinogenesis, influencing both the inhibition and the production of cancer. It is of great importance to increase the knowledge about this process because it could be used as a valuable tool in the treatment of this disease.